94 research outputs found

    Power Sharing and the Rule of Law in the Aftermath of Civil War

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    What effect do power-sharing institutions agreed to as part of civil war settlements have on the development of the rule of law in post–civil war states? We contend that power-sharing measures facilitate the emergence of the rule of law in two ways. First, they establish a form of institutional constraint that promotes judicial autonomy and independence. Second, they foster a sense of security among judges and other political actors that bolsters commitment to the law. We demonstrate the plausibility of a positive relationship between power sharing and the rule of law through an analysis of post–civil war states between the years 1948 and 2006. Our findings suggest that civil war settlements can help to establish the rule of law when they include mechanisms aimed at allaying the insecurities of political actors in the postconflict environment

    Power Sharing and Democracy in Post-Civil War States: The Art of the Possible

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    Power Sharing and Democracy in Post-Civil War States examines the challenge of promoting democracy in the aftermath of civil war. Hartzell and Hoddie argue that minimalist democracy is the most realistic form of democracy to which states emerging from civil war violence can aspire. The adoption of power-sharing institutions within civil war settlements helps mitigate insecurity and facilitate democracy\u27s emergence. Power sharing promotes \u27democratization from above\u27 by limiting the capacity of the state to engage in predatory behavior, and \u27democratization from below\u27 by empowering citizens to participate in politics. Drawing on cross-national and case study evidence, Hartzell and Hoddie find that post-civil war countries that adopt extensive power sharing are ultimately more successful in transitioning to minimalist democracy than countries that do not. Power Sharing and Democracy in Post-Civil War States presents a new and hopeful understanding of what democracy can look like and how it can be fostered.https://cupola.gettysburg.edu/books/1171/thumbnail.jp

    The Related Transcriptional Enhancer Factor-1 Isoform, TEAD4216, Can Repress Vascular Endothelial Growth Factor Expression in Mammalian Cells

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    Increased cellular production of vascular endothelial growth factor (VEGF) is responsible for the development and progression of multiple cancers and other neovascular conditions, and therapies targeting post-translational VEGF products are used in the treatment of these diseases. Development of methods to control and modify the transcription of the VEGF gene is an alternative approach that may have therapeutic potential. We have previously shown that isoforms of the transcriptional enhancer factor 1-related (TEAD4) protein can enhance the production of VEGF. In this study we describe a new TEAD4 isoform, TEAD4216, which represses VEGF promoter activity. The TEAD4216 isoform inhibits human VEGF promoter activity and does not require the presence of the hypoxia responsive element (HRE), which is the sequence critical to hypoxia inducible factor (HIF)-mediated effects. The TEAD4216 protein is localized to the cytoplasm, whereas the enhancer isoforms are found within the nucleus. The TEAD4216 isoform can competitively repress the stimulatory activity of the TEAD4434 and TEAD4148 enhancers. Synthesis of the native VEGF165 protein and cellular proliferation is suppressed by the TEAD4216 isoform. Mutational analysis indicates that nuclear or cytoplasmic localization of any isoform determines whether it acts as an enhancer or repressor, respectively. The TEAD4216 isoform appears to inhibit VEGF production independently of the HRE required activity by HIF, suggesting that this alternatively spliced isoform of TEAD4 may provide a novel approach to treat VEGF-dependent diseases

    The Art of the Possible: Power Sharing and Post— Civil War Democracy

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    Although there is now a wealth of scholarship concerning the onset, duration, and termination of civil wars, there is not nearly as much empirical research by political scientists on the potential for postconflict democratization in countries that have been the site of civil wars. This relative scholarly neglect of post–civil war democratization stands in contrast to the efforts and resources that other actors—foreign ministries, international and nongovernmental organizations, and members of civil society—have invested in attempting to help construct democracy in postconflict states such as Indonesia, Liberia, and Uganda. [excerpt

    Short-Term Pain, Long-Term Gain? The Effects of IMF Economic Reform Programs on Public Health Performance

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    In this study, we evaluate the effects of the International Monetary Fund’s structural adjustment programs (SAPs) on the public health performance of countries. We test the claim made by proponents of SAPs that although these programs may produce short-term hardship for the countries adopting them, they will generate positive developmental effects in the long term. Methods. Our study draws on a global data set and employs a model that takes into account the potential for selection bias in the adoption of SAPs by states. Results. The central finding of the article is that SAPs in the short term raise the exposure of populations to conditions that increase incidences of disability and death. Contrary to the assertions made by the advocates of SAPs, we also find evidence that these programs have attenuated but still harmful effect on public health performance in the long term. Conclusions. This study highlights the negative influences of SAPs on public health and suggests that a need exists to reevaluate the claims that have been made regarding the developmental effects of these programs. [excerpt

    Externally Mandated Economic Liberalization and the Onset of Civil Conflict

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    This chapter focuses on the impact that IMF structural adjustment programs may have in weakening the state and thus increasing the likelihood of civil war onset
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